The United Arab Emirates' General Civil Aviation Authority said it crashed about five kilometres south of the airport after setting out "to calibrate land navigation devices at Dubai International Airport".
Following the crash flights were delayed and diverted as the airport - one of the world's busiest, based on global passenger traffic - was closed for 45 minutes.
It is unclear whether the plane was taking off or landing when the tragedy unfolded.More news: Bluetooth pairing bug forces Google to recall select Titan Security Keys
"An accident involving a small plane with four passengers occurred resulting in the death of the pilot and his assistant".
An UK Foreign and Commonwealth Office spokesperson said: "We are working closely with the Emirati authorities following reports of a small aircraft crash in Dubai".More news: Ways To Reduce Your Risk Of Dementia, According To A New Report
Operations were affected between 7.36 pm and 8.22 pm UAE local time, after which flights resumed from the airport.
According to the BBC, three Britons and a South African tragically lost their lives around three miles south of Dubai International Airport last night (May 16).
The Diamond DA42 aircraft is described on the Diamond website as having a "high degree of crashworthiness" and being "easy to fly and burns fuel like a single, but with the added safety of a second engine". It was owned by the American conglomerate, Honeywell. "We are deeply saddened by the news that a small, chartered plane crashed in Dubai yesterday evening and our heartfelt condolences are with the victims' families". We are waiting for more details'.More news: USA pregnant teen slain, baby cut from womb
- Trump lifts tariffs on Mexico and Canada amid China trade dispute
- American justice system 'largely evil', says Conrad Black after Trump's pardon
- Cardinals star Patrick Peterson gets 6-game suspension for PEDs
- Fans mourn as internet-famous Grumpy Cat dies aged 7
- China formally arrests 2 Canadians in case linked to Huawei
- US State Department orders all non-essential government personnel to leave Iraq
- This Was Aaron Rodgers' Cameo in 'Game of Thrones'
- China warns USA against trade 'harm' over Huawei ban
- Xiaomi Redmi Note 7S India Launch Confirmed: Price, Specs, Features, Availability & More!
- Frank Lampard mocks Leeds fans by singing 'stop crying Frank Lampard' song