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1st baby born using uterus transplanted from deceased donor

05 December 2018

A woman in Brazil has successfully given birth after receiving a womb from a dead donor, the first time such a procedure has been successful.

The birth followed ten unsuccessful attempts, according to the authors of the new study.

The transplanted uterus was removed during the C-section, allowing the woman to stop taking the immunosuppressive drugs.

We wish her a happy first birthday.

Those possibilities, paired with improved surgical practices, means uterus transplantation could someday become a standard procedure, Ejzenberg says. The demonstrated success of a procedure involving a deceased donor, he says, may spare live donors from undergoing risky procedures, and make transplants possible for far more women.

Three teams in the us, including O'Neill's, are now working on uterine transplants.

This represents a major advance in reproductive health.

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Women who would be candidates for a uterus transplant would have absolute uterine infertility, meaning they don't have a uterus or that it is too damaged to support a pregnancy.

Thus the hope that deceased donors could be another source of organs.

"Successful pregnancy, without evidence of any compromise in spite of the uterus (womb) being without oxygen for eight hours before transplant, was unique".

Uterine transplantation is a multi-step process that requires coordination among numerous physicians.

He said live uterus donors are rare and typically eligible family members or close friends of women seeking the transplant.

Women who have irreversible infertility are the primary candidates to receive a transplant.

Infertility affects 10- to 15 per cent of couples. The causes vary, but for one in 500 women, uterine problems are the cause. She has a disease called Mayer-Rokitansky-Kuster-Hauser Syndrome, commonly known as congenital uterine absence. The woman had ovaries and a vagina, but no uterus.

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Procedures using organs from live donors have been attempted 39 times in the years since, so far resulting in a total of 11 live births.

The major risks associated with this process are organ rejection through blood type mismatch, inadequate immune system suppression or severe infection of the transplanted organ.

The fertilised eggs were implanted after seven months. Normal prenatal testing including blood sugar tests and ultrasounds were all done and returned without any abnormalities. The woman - a 32-year-old psychologist - was initially apprehensive about the transplant, said Dr. Dani Ejzenberg, the transplant team's lead doctor at the University of Sao Paulo School of Medicine.

Is a uterus transplant permanent?

"Just as cornea, kidney, liver, heart, the pancreas, I am hopeful that the uterus will also be added in the gamut of organs taken out so that many more people will be benefited", Ms Rao noted. In this case, a cesarean section was performed for birth at 35 weeks gestation, and along with the delivery of an nearly 6 pound healthy baby girl, the uterus was also removed.

After surgery, the anonymous recipient remained in intensive care for two days before spending another six days on a specialised transplant ward.

However this advance serves as motivation to expand prospects for a novel technique in giving some women a chance at childbirth by greatly enlarging the potential donor population.

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1st baby born using uterus transplanted from deceased donor