Anderson will play again in the final on Sunday - hopefully there, a victor will be decided in four sets or less. Djokovic retired in that match because of a toe blister.
While both of those Nadal victories came on clay, they may set the tone for how this match begins.
"I'm a proponent of changing that rule, for sure".
"I don't really know what to say right now", said Anderson.
"Friday is another important match against an opponent that is one of the most hard ones that you can face".More news: Meghan, Duchess of Sussex joins The Queen for second balcony appearance
It's his second showpiece appearance in four major tournaments after his runner-up finish in last year's US Open.
There were a total of 102 aces in a match with Isner serving 53 aces and Anderson serving 49.
The two have played some memorable matches over the years.
The only break point in set number two came in game nine when John saved it to keep his serve intact for another set, and this time he was the better player in the tie break, racing into a 5-0 lead and closing it 7-5 to level the overall score at 1-1 after two hours of play. It was past 8 p.m.in London when Anderson and Isner wrapped up, meaning the second semifinal could extend into Saturday.
Novak Djokovic clawed his way to a two sets to one lead over great rival Rafael Nadal under the Centre Court roof before their scintillating Wimbledon semi-final was paused with the contest balanced on a knife-edge on Friday. But if and when Djokovic does break serve, or win a set, or save a set point, or do something to fire himself up and sow doubt in Nadal's head, all of that could be turned upside-down in a hurry, the same way their rivalry has been turned upside-down in a hurry in the past.
Some did see the amusing side, providing some alternative statistics to what was officially the longest ever Wimbledon semi-final. At 13-13 in the final set, one spectator screamed "we want to see Rafa!"More news: Anderson, Isner in second-longest Wimbledon singles match
When Kevin Anderson lost his footing and fell on his backside while hitting a backhand in the men's semi-final at Wimbledon on Friday nobody would have blamed him if he did not bother getting up again.
Moreover, Djokovic has historically been a better grass-court player and could potentially be a little more rested, as he wasn't pushed almost as hard in his quarterfinal matchup.
"If you ask majority, I'm sure they would have preferred to see a fifth-set tiebreaker, too".
"For us to be out there this length of time - I mean, not just on us, but coming back trying to compete at this sort of stage, going through this - it's happened to John before, when he's played another five hours".
That service hold - helped by a 129 miles per hour (207.6km/h) second serve - took the American to 100 service games unbroken at this Wimbledon.More news: 128 dead following blast at Pakistan election rally
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