Rafael Nadal has breezed into his first Wimbledon quarter-final since 2011.
Federer fired another warning to his title rivals in another very complete performance.
Defending champion Roger Federer sauntered into the Wimbledon quarterfinals with a dominant display Monday, beating Adrian Mannarino 6-0, 7-5, 6-4.
Mannarino was never allowed to settle as an ultra-aggressive Federer executed some sublime winners from the back of the court.
Mannarino won only two points in the first five games and the opening set was brought to an end inside just 16 minutes.
Del Potro saved two break points in the sixth game, a deft chip from the baseline that dipped over the net followed by a forehand victor, before taking the opening set in a 7-1 tiebreak.More news: Queen and Prince Philip to miss Prince Louis' christening
The Czech gifted Nadal the one break he needed to win the first set with a double-fault, but the Spaniard took matters into his own hands in the second, clubbing two forehand winners to grab one break and winning the set on Vesely's serve with a sliced victor as his opponent lumbered forward.
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Should number 103 Mackenzie McDonald defeat former runner-up Milos Raonic later Monday, it will be the first time since 2000 that two men outside the top 100 have made the Wimbledon quarter-finals.
"It was an important victory as since 2011 I have not been in the quarterfinals of Wimbledon". I didn't think that was ever going to happen.
"I actually did get a bit emotional that I was in the last 16 of a Grand Slam that I have been dreaming of winning one day", Tsitsipas said.
Williams, who is seeking an eighth Wimbledon title, was even more efficient, needing 62 minutes to dispatch the 120th-ranked Evgeniya Rodina, 6-2, 6-2. "I can only take positives out of this Grand Slam". He rarely drops service and tends to win points on the first serve rather than wasting effort and going to a second.More news: Young: England haven't won anything yet
But is the Serb's recovering game sound enough yet, or his elbow sufficiently strong to keep rattling down those aces, to intimidate a player made in Edmund's power-play mode, Karen Khachanov, in the third match on No 1 Court on Monday?
He added: 'There's a good chance it's going to come down to a few points here and there.
If Anderson is to shock Federer, who has only lost once before the quarter-finals at Wimbledon in 15 years, he will need to call up the heavy artillery which has served him well at the tournament this year.
"I feel like a lot of aspects of my game can give him a lot of trouble", said Anderson, the first South African man in the Wimbledon quarter-finals since Wayne Ferreira in 1994. He will face Djokovic next in his first quarterfinals appearance at the All England Club.
Gulbis has played 3 successive 5-set matches to get this far and is bidding to become just the 6th qualifier to reach the last-8 at Wimbledon.More news: IOS 11.4.1 brings USB Restricted Mode but it has a bug
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