It's also the only Grand Slam tournament in the half-century professional era with zero top-10 seeds in the women's final eight.
Federer, who has won 32 consecutive sets at the tournament and held serve 81 games in a row, was asked whether he paused for even a moment to wonder why he wasn't being given more of a test. And Williams was followed by Rafael Nadal - two titles at Wimbledon, 17 at all Slams - who dispatched 93rd-ranked Jiri Vesely of the Czech Republic 6-3, 6-3, 6-4.
"It never happened to me that the umpire changed the decision", Cibulkova said.
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Since seeds were introduced in the 1920s, it's the first time none of the top-10 have reached the women's quarterfinals at Wimbledon. "You still have to beat the players".
Bidding for an eighth championship at the All England Club, Williams will be back on court Tuesday, but she is seeded only 25th, and that actually represents a big bump up from her ranking of No. 181. I know a lot of people won't like that, but I don't care'.
The 22nd-seeded Mannarino became the first man to earn a break point against Federer at the tournament, but was unable to take any of his four opportunities.
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The 21-year-old Ostapenko, the youngest player remaining in the women's draw, next faces 33rd-ranked Dominika Cibulkova of Slovakia.
Next up for the 23-time Grand Slam victor is Italy's Camila Giorgi, who is making her debut in the quarter-finals of a major.
Next up for Kerber is Russian 14th seed Daria Kasatkina, who took out Belgian Alison Van Uytvanck 6-7 (6-8) 6-3 6-2. "I'm just going for the shots". The only fourth-round match that wasn't completed on Monday - fifth-seeded Juan Martin del Potro against Frenchman Gilles Simon - will also be played to a finish.
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The quarter-final line-up is looking like the land of the giants, with 6ft 8in Kevin Anderson of South Africa beating Frenchman Gael Monfils 7-6, 7-6, 5-7, 7-6. "But when I come here, I come here thinking that I can do a good result, no?"
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