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Immunotherapy for Prostate Cancer Could Have Spectacular Results

06 June 2018

The team at the Institute of Cancer Research and the Royal Marsden Hospital in London said the results were "spectacular" and a "big deal".

United Kingdom doctors have discovered that immune system boosting drugs have shown success rates in saving the life of men who are suffering with terminal prostate cancer diagnosis. However, more than a third of those men who have been treated with a new drug, could stop the proliferation of malignant cells.

Researcher Prof Johann de Bono told the BBC: "This is the first evidence that a subset of prostate cancer patients do spectacularly well on immunotherapy".

Yes! Now the prostate cancer patients with hardly weeks or months to live will be able to survive longer if they are subjected to proper immunotherapy treatment.

Around 38% were still alive after a year and 11% did not see the cancer grow, the results show.

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Nonetheless, for sufferers reminiscent of these within the new examine with docetaxel-refractory metastatic castration-resistant prostate most cancers, there may be at present no efficient therapy.

The earlier trails conducted using immunotherapy in prostate cancer did not prove to be successful.

Immunotherapy, which personalizes treatment based on the genetic make-up of tumors, is only successful for a minority of patients, professor Paul Workman, chief executive of the ICR, said in a statement.

Just 5 percent of men in the trial saw their tumours actually shrink or disappear after treatment, but the proportion was higher in a small group of men whose tumours had mutations to genes involved in repairing DNA, the researchers noted. It is an IgG4 isotype antibody that blocks a protective mechanism of cancer cells, and allows the immune system to destroy those cancer cells.

Immunotherapy is transforming the treatment of cancer and is now part of routine practice for some skin and lung cancers.

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However, the therapy will not work for most patients.

Unfortunately, only 10 - 15% of the patients responded to immunotherapy, making the approach ineffective for the majority of prostate cancer patients.

The researchers also said that some of the patients who had substantial responses to the treatment have tumors that may have mutations in the genes that control DNA fix, an important cellular process that maintains the genome.

The disease is the most common form of male cancer: one in eight will be diagnosed with it during their lifetime. This study should serve as a call for the entire cancer research community to make trials much more inclusive.

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Immunotherapy for Prostate Cancer Could Have Spectacular Results