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70 per cent breast cancer patients don’t need chemo

05 June 2018

The results "should have a huge impact on doctors and patients", Albain said. The findings indicate that chemotherapy may be considered for the remaining 30% of women. "We can de-escalate toxic treatments and do that with certainty".

Judy Perkins, an engineer from Florida, was 49 when she was selected for the radical new therapy after several rounds of routine chemotherapy failed to stop a tumour in her right breast from growing and spreading to her liver and other areas.

"The more in the bad risk category we'd say the chances of the cancer coming back are high so we'd give aggressive chemotherapy but still it wasn't an accurate science", explained Dr. Imran.

"Chemotherapy is no Shangri-La", Brawley said.

This study supports sparing thousands of women from the sometimes nasty side effects of chemotherapy, but we must be crystal clear that it applies to a very specific (and significant) subset of women. A new U.S. study, TAILORx, has shown that up to 70% of these women could avoid this painful treatment, which has multiple side effects.

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"Metastatic breast cancer remains incurable, and if we are to finally stop women dying we urgently need to find new ways to target and stop the spread of the disease. It felt like the worst flu I'd ever had times ten, and you have absolutely no energy".

A new study presented yesterday (June 3) at an American Society of Clinical Oncology meeting in Chicago, Illinois, suggests that about half of the women who are diagnosed with a subset of early-stage breast cancer may not need chemotherapy as part of their post-surgery treatment. But the researchers who conducted this new controlled experiment found that chemotherapy provided no additional benefit over hormone treatments alone.

The researchers were specifically interested in women who scored 10 to 25 on the test - scores that fall in the range of a medium risk of the cancer returning after surgery.

The patients in this group were randomly assigned to chemotherapy with supplemental hormone therapy or just hormone therapy alone.

St Vincent's University Hospital in Dublin had the second highest number of participating patients from the 1,182 research units involved. She's still cancer-free two years later.

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In the USA, the most recent data shows around 135,000 new cases yearly of the specific breast cancer studied, says Dr. Joseph Sparano, an oncologist at Montefiore Medical Center, a professor of medicine at the Albert Einstein College of Medicine and the lead author of the study.

After enrolling for new trial in 2015, doctors in the USA adopted an experimental approach combining two different forms of immunotherapy after conventional hormone treatments and chemotherapy failed. Before the new treatment, doctors had given her three years to live. Because of that, many women with early-stage cancer used to be urged to get chemotherapy in hopes of preventing any spread.

Jennifer Litton, an associate professor and oncologist at MD Anderson Cancer Center in Houston, told USA Today that the results will help patients and their doctors make more informed decisions.

The extensive study revealed that approximately 70 percent of women diagnosed with early-stage breast cancer might not benefit from a treatment protocol that includes chemotherapy.

"If confirmed in a larger study, it promises to further extend the reach of this T-cell therapy to a broader spectrum of cancers", he said. Dr. Laszlo Radvanyi of the Ontario Institute for Cancer Research in Toronto described it as "an unprecedented response in such advanced breast cancer".

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70 per cent breast cancer patients don’t need chemo