But after his second-round match against Federico Delbonis which started at 8 p.m. Saturday night was halted due to rain with Federer up 6-3, 2-2, the match resumed Sunday and ended at about 4 p.m. with Federer winning 6-3, 7-6.
Sousa eventually prevailed 7-5 5-7 6-4 to set up a third round match against Milos Raonic, who beat 17-year-old countryman Felix Auger-Aliassime 6-4 6-4.
Taro Daniel, a 109th-ranked qualifier, upset five-time Indian Wells champion Novak Djokovic 7-6 (3), 4-6, 6-1.
Frenchman Gael Monfils survived a match point before beating big-serving American John Isner 6-7 (5) 7-6 (3) 7-5 in a contest that had only one break.
As his form began to dip at the end of 2016, Djokovic admitted that he had been affected by off-court issues that he hasn't elaborated on.More news: 'Chilling': Virat Kohli shares picture of wife Anushka Sharma kissing him
"I made so many unforced errors that it was just one of those days where you are not able to find the rhythm from the baseline especially from the backhand side".
Djokovic shut down his season after Wimbledon in 2017 and despite not being at his best, chose to play at this year's Australian Open where he was ousted by South Korea's Hyeon Chung in the fourth round.
Federer won the Indian Wells championship for a fifth time previous year, adding to his crowns in the Southern California desert in 2004, 2005, 2006 and 2012.
"And even though you don't have pain, you're still thinking about it, because it's been something that I have been feeling and dragging for over two years".
"It's been a long time since I have been interrupted at night and have to come back the next day", Federer said.More news: 'A harrowing five minutes': Dallas-bound flight makes emergency landing in Albuquerque
"But it's not easy to deal with this kind of frustrations after injuries or when you always be the favorite to win a tournament, you come here and you lose in first round".
"Maybe it was because it was the first time he ever played against me". It is still early stages for Novak coming back and the first one after surgery. The two instead played Sunday afternoon and Stephens looked very sharp in dispatching Azarenka 6-1, 7-5.
Other seeded players who lost were ninth-seeded Lucas Pouille, who fell 6-4, 6-4 to Yuki Bhambri; 14th-seeded Diego Schwartzman, 7-5, 6-4 to Marcos Baghdatis; 21st-seeded Kyle Edmund, 6-4, 6-4 to Dudi Sela; and No. 24 seed Giles Muller, 6-3, 7-5 to Pierre-Hugues Herbert.
The win sets up a third round showdown with Spaniard David Ferrer who defeated Tennys Sandgren of the USA 6-2, 7-6 (7/3).More news: European Union extends Russian Federation sanctions for 6 more months for meddling in Ukraine
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