"I've had my ass grabbed by older, powerful men", the actor wrote.
"I've had my ass grabbed by older, powerful men, I've had them corner me in inappropriate sexual conversations when I was much younger..."
Multiple stars have come forward since the New York Times expose accusing Weinstein of decades of sexual harassment and abuse.
Upon sharing an article of a woman relating her harassment experience, the former Dawson's Creek actor wrote: "For anyone judging the women who stayed silent, read this for perspective". "I applaud everybody speaking out", he began.More news: Sergio Aguero coy on Manchester City return date
The 40-year-old added that he understood "the unwarranted shame, powerlessness and inability to blow the whistle". "There's a power dynamic that feels impossible to overcome", he continued, empathising with women who have gone through similar or even worse cases of sexual assault.
Van Der Beek joins "Everybody Hates Chris" star Terry Crews, who on Tuesday tweeted that he had been groped by a "high level Hollywood executive". His film credits include Varsity Blues (1999) and The Rules of Attraction (2002).
James isn't the only male Hollywood star to come forward with a tale of sexual harassment.
"This whole thing with Harvey Weinstein is giving me PTSD. Why?"More news: General Electric Company (GEC.L) Sees The Tape Move Mid-Market
'That night and the next day I talked to everyone I knew that worked with him about what happened, ' Terry tweeted.
"Jumping back I said What are you doing?!" "I understand the shame is unjustified, the inability to say stop". My wife saw everything n we looked at him like he was insane. "'240 lbs. Black Man stomps out Hollywood Honcho' would be the headline the next day", he wrote.
Weinstein has strongly denied rape allegations and said many other accusations against him are inaccurate.More news: Chris Johnson's Forecast | Showers and storms set to increase
And Rosanna Arquette and Mira Sorvino said that their careers suffered after Weinstein forced himself upon them and they fought him off.
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