Andy Murray surrendered a 4-0 lead in the decisive third set on his way to defeat at the Monte Carlo Masters on Thursday as the world number one s 2017 season hit another setback.
Andy Murray survived a bit of a scare to win his first tennis match back after an elbow injury.
In the day's other matches, third-ranked Stan Wawrinka overcame Jiri Vesely 6-2 4-6 6-2 while fifth seed Marin Cilic dismantled Jeremy Chardy 6-3 6-0 and Alexander Zverev looked invincible against Feliciano Lopez to seal a 6-0 6-4 win.
Murray was kept on the back foot in the opening set as he lost the first game and only caught up late.
"I wouldn't start the tournament unless I felt comfortable, but I've only been really serving at my normal pace the last couple of days", Murray said in an interview on the ATP Tour website ahead of his second round match on Wednesday.More news: 'Incontrovertible' sarin gas used in Syria: watchdog
Also on Tuesday, top French player Jo-Wilfried Tsonga was shocked 7-6 (3), 2-6, 3-6 by fellow Frenchman Adrian Mannarino in his first match since the birth of his son, reports Xinhua news agency.
Djokovic dropped five straight games from 2-0 up in the second set and had to dig deep against the gritty Spaniard, whose speed across the court saw him retrieve countless shots.
It might have been different had the Spaniard capitalised after winning a long game to break the Edmund serve for 2-1.
Nadal, who was taken to five sets by Zverev at the Australian Open earlier this year, will now face Diego Schwartzman of Argentina in the next round.
The next match could be tough, too.More news: Injured soccer player: bus attack 'hardest 15 minutes of my life'
He will not be able to get his revenge on Federer here, since the 18-time Grand Slam champion is skipping the tournament.
The Scot has improved his fortunes on clay over the last two years, when previously it had been his weakest surface.
Second seed Novak Djokovic was stretched by Pablo Carreno Busta, but made it through to the quarterfinals with a 6-2, 4-6, 6-4 third-round victory.
Murray's enforced absence at least gave him the added bonus of spending more time with his wife and young daughter. "I couldn't get the breakthrough until right at the end". "It was very tiring for me, the first clay of the season".
Ninth-seeded Tomas Berdych, the runner-up here in 2015, rallied to beat 39-year-old German Tommy Haas 3-6, 6-1, 6-4.More news: Illinois lawmakers ponder proposal to legalize marijuana
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