Madrid host Barca with a three-point lead at the top of La Liga and with a game in hand.
With him out, Barca may go with Paco Alcacer in attack with Luis Suarez and Lionel Messi, but we'll get a better idea when we see the team's lineup for the clash against Juventus on Wednesday in the Champions League.
Ahead of the big game, a couple of Squawka's most trusted employees, Nic English and Muhammad Butt, took to Federation Internationale de Football Association 17 to see who could come out on top between Real Madrid and Barcelona, with interesting results...More news: Former Tennessee teacher in kidnapping case captured, girl safe
The analysis revealed that the combined TV and social media value of the last El Clásico in December 2016 generated around $42.5m for sponsors. It is the end of an era and then suddenly you win two or three Leagues.
The Spaniard is a lifelong Real Madrid fan and was promised the ceremonial honour at the iconic Estadio Santiago Bernabeu by the club after his first major victory. Though opinions are just as strong that the man who truly deserves that title is Real Madrid's Cristiano Ronaldo. We were eliminated by Bayern Munich and everyone was thinking that we were going to lose at Camp Nou 3, 4, 5-nil, 6-nil, things like that. "We need the three points", Barcelona midfielder Ivan Rakitic said.
"I hope it is nothing and in a few days he can be with us again". So, believe me, an "El Clasico" is different, it doesn't matter the position on the table, it doesn't matter what happened the last week, the last month, the last day.More news: Utah Jazz center Jeff Withey faces domestic violence probe
The Catalans contested the decision as they feel both the player and the club have an impeccable disciplinary record - it was the first dismissal in a Blaugrana shirt for the Brazil worldwide and a first in La Liga for his team since October 2015.
"The world grinds to a halt to watch this game", Madrid left back Marcelo said. But this would mark the first time since 2012 that it hasn't won La Liga or the Champions League or both.
Ramos, according to Marca, took exception to Pique's latest flaming of Real Madrid, and it wasn't hard for the Real Madrid captain to think of a retort.More news: BP's leaking Alaska well stops spraying crude oil, still emitting gas
The other players warmed up before taking part in rondo style drills, before playing a game on a reduced size pitch. "Obviously, he needs to sign some players but the end of an era, I wouldn't say that", he added.
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