The Gunners boss came under even more pressure at Selhurst Park after relegation candidates Palace eased to a comfortable win against the top-four contenders.
With a visit of London rivals West Ham to come, Wenger again asked for patience when questioned over his future.
Arsenal great Ian Wright said the nature of Arsenal's latest capitulation showed the "dressing room is lost".
However, Arsenal did confirm that they are not expecting an announcement to be made on Wenger's future before the end of the season when a "mutual decision will be communicated in the right way", reiterating the statement made by chairman Sir Chips Keswick last month.More news: Wasps stunned as England lock Joe Launchbury misses out on Lions squad
"Now it's time for him to go", Hartson said, saying Arsenal's showing against Palace was "inept - there was a lack of leadership, a lack of togetherness".
Former Tottenham Hotspur defender Graham Roberts slammed his display, arguing that he would not want Ozil in the Spurs team, putting his point across that there are two players he would rather pick.
"I wouldn't say that (my players didn't give 100%)", Wenger said.
As well as a awful run of form which has seen Arsenal drop out of the Premier League title picture and face an uphill battle to finish in the top four, there has also been a backdrop of protests over Wenger's future. I've managed over 1 000 games and we are not used to this, it's a big worry.More news: France claims to prove Syria's use of chemical weapon "in few days"
Insisting that every defeat is a big worry for him, the 67-year-old said that his team need to respond very quickly and not accept the humiliating defeat. "We won a lot of possession off them and won a lot of chances off them".
"It was more painful for us to lose this game in the way we lost it".
"We thought we had got out of this little patch and hopefully we haven't been dragged straight back into it. Judging on that performance, it looks like we have".
Wenger has so far refused to let fans know whether he is going to continue at Arsenal next season but there is talk that the Frenchman will ultimately sign a new contract.More news: Airline crew delivers baby girl mid-flight
Captain Theo Walcott apologised to fans after Arsenal conceded three goals for a fourth consecutive away league game, and acknowledged: "you could sense from the kickoff that wanted it more".
- What Are Snap Elections? What to Know Ahead of June 8
- Microsoft buys startup to boost its cloud
- Defense team to conduct own probe of Aaron Hernandez death
- Browns zero in on No. 1 pick, trade for veteran QB unlikely
- Short Interest in Bristol-Myers Squibb Co (BMY) Declines By 32.8%
- Israel not to negotiate with Palestinian hunger strikers: minister
- Penguins beat Blue Jackets in OT, Canadiens defeat Rangers
- Crystal Palace vs Leicester City 15th April 2017: EPL Preview and Predictions
- North Korea is 'getting the message': US Vice Prez Pence
- No contrition from Nets' for capitulation that capsized Heat